Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis

The degradation of tryptophan (TRP) along the kynurenine pathway plays a crucial role as a neuro- and immunomodulatory mechanism in response to inflammatory stimuli, such as lipopolysaccharides (LPS). In endotoxemia or sepsis, an enhanced activation of the rate-limiting enzyme indoleamine 2,3-dioxyg...

Descripción completa

Detalles Bibliográficos
Autores principales: Wirthgen, Elisa, Hoeflich, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736209/
https://www.ncbi.nlm.nih.gov/pubmed/26881062
http://dx.doi.org/10.1155/2015/973548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736209/
https://www.ncbi.nlm.nih.gov/pubmed/26881062
http://dx.doi.org/10.1155/2015/973548

Ejemplares similares