Copper‐Catalyzed Double Additions and Radical Cyclization Cascades in the Re‐Engineering of the Antibacterial Pleuromutilin

A general synthetic sequence involving simply prepared starting materials provides rapid access to diverse, novel tricyclic architectures inspired by pleuromutilin. Sm(II)‐mediated radical cyclization cascades of dialdehydes, prepared using a new, one‐pot, copper‐catalyzed double organomagnesium add...

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Detalles Bibliográficos
Autores principales: Ruscoe, Rebecca E., Fazakerley, Neal J., Huang, Huanming, Flitsch, Sabine, Procter, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736435/
https://www.ncbi.nlm.nih.gov/pubmed/26527052
http://dx.doi.org/10.1002/chem.201504343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736435/
https://www.ncbi.nlm.nih.gov/pubmed/26527052
http://dx.doi.org/10.1002/chem.201504343

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