ADMET evaluation in drug discovery: 15. Accurate prediction of rat oral acute toxicity using relevance vector machine and consensus modeling

BACKGROUND: Determination of acute toxicity, expressed as median lethal dose (LD(50)), is one of the most important steps in drug discovery pipeline. Because in vivo assays for oral acute toxicity in mammals are time-consuming and costly, there is thus an urgent need to develop in silico prediction...

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Detalles Bibliográficos
Autores principales: Lei, Tailong, Li, Youyong, Song, Yunlong, Li, Dan, Sun, Huiyong, Hou, Tingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736633/
https://www.ncbi.nlm.nih.gov/pubmed/26839598
http://dx.doi.org/10.1186/s13321-016-0117-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736633/
https://www.ncbi.nlm.nih.gov/pubmed/26839598
http://dx.doi.org/10.1186/s13321-016-0117-7

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