Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

RAF kinases are key players in the MAPK signaling pathway and are important targets for personalized cancer therapy. RAF dimerization is part of the physiological activation mechanism, together with phosphorylation, and is known to convey resistance to RAF inhibitors. Herein, molecular dynamics simu...

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Detalles Bibliográficos
Autores principales: Jambrina, Pablo G., Rauch, Nora, Pilkington, Ruth, Rybakova, Katja, Nguyen, Lan K., Kholodenko, Boris N., Buchete, Nicolae‐Viorel, Kolch, Walter, Rosta, Edina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736688/
https://www.ncbi.nlm.nih.gov/pubmed/26644280
http://dx.doi.org/10.1002/anie.201509272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736688/
https://www.ncbi.nlm.nih.gov/pubmed/26644280
http://dx.doi.org/10.1002/anie.201509272

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