Structural role of two histidines in the (6-4) photolyase reaction

Photolyases (PHRs) are DNA repair enzymes that revert UV-induced photoproducts, either cyclobutane pyrimidine dimers (CPD) or (6-4) photoproducts (PPs), into normal bases to maintain genetic integrity. (6-4) PHR must catalyze not only covalent bond cleavage, but also hydroxyl or amino group transfer...

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Detalles Bibliográficos
Autores principales: Yamada, Daichi, Iwata, Tatsuya, Yamamoto, Junpei, Hitomi, Kenichi, Todo, Takeshi, Iwai, Shigenori, Getzoff, Elizabeth D., Kandori, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2015
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736838/
https://www.ncbi.nlm.nih.gov/pubmed/27493863
http://dx.doi.org/10.2142/biophysico.12.0_139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736838/
https://www.ncbi.nlm.nih.gov/pubmed/27493863
http://dx.doi.org/10.2142/biophysico.12.0_139

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