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Structural role of two histidines in the (6-4) photolyase reaction
Photolyases (PHRs) are DNA repair enzymes that revert UV-induced photoproducts, either cyclobutane pyrimidine dimers (CPD) or (6-4) photoproducts (PPs), into normal bases to maintain genetic integrity. (6-4) PHR must catalyze not only covalent bond cleavage, but also hydroxyl or amino group transfer...
Autores principales: | Yamada, Daichi, Iwata, Tatsuya, Yamamoto, Junpei, Hitomi, Kenichi, Todo, Takeshi, Iwai, Shigenori, Getzoff, Elizabeth D., Kandori, Hideki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society of Japan (BSJ)
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736838/ https://www.ncbi.nlm.nih.gov/pubmed/27493863 http://dx.doi.org/10.2142/biophysico.12.0_139 |
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