Genetic variants at HbF‐modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania

Fetal hemoglobin (HbF) is a recognized modulator of sickle cell disease (SCD) severity. HbF levels are strongly influenced by genetic variants at three major genetic loci, Xmn1‐HBG2, HMIP‐2, and BCL11A, but the effect of these loci on the hematological phenotype in SCD, has so far not been investiga...

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Detalles Bibliográficos
Autores principales: Mtatiro, Siana Nkya, Makani, Julie, Mmbando, Bruno, Thein, Swee Lay, Menzel, Stephan, Cox, Sharon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
E‐ONLY Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737118/
https://www.ncbi.nlm.nih.gov/pubmed/25263325
http://dx.doi.org/10.1002/ajh.23859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737118/
https://www.ncbi.nlm.nih.gov/pubmed/25263325
http://dx.doi.org/10.1002/ajh.23859

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