Cargando…

Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

OBJECTIVE: Rituximab, a type I anti‐CD20 monoclonal antibody (mAb), induces incomplete B cell depletion in some patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), thus contributing to a poor clinical response. The mechanisms of this resistance remain elusive. The purpose...

Descripción completa

Detalles Bibliográficos
Autores principales: Reddy, Venkat, Cambridge, Geraldine, Isenberg, David A., Glennie, Martin J., Cragg, Mark S., Leandro, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737120/
https://www.ncbi.nlm.nih.gov/pubmed/25916583
http://dx.doi.org/10.1002/art.39167