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Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

OBJECTIVE: Rituximab, a type I anti‐CD20 monoclonal antibody (mAb), induces incomplete B cell depletion in some patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), thus contributing to a poor clinical response. The mechanisms of this resistance remain elusive. The purpose...

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Detalles Bibliográficos
Autores principales:	Reddy, Venkat, Cambridge, Geraldine, Isenberg, David A., Glennie, Martin J., Cragg, Mark S., Leandro, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Rheumatoid Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737120/ https://www.ncbi.nlm.nih.gov/pubmed/25916583 http://dx.doi.org/10.1002/art.39167

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