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A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine–DNA glycosylase
In contrast to proteins recognizing small-molecule ligands, DNA-dependent enzymes cannot rely solely on interactions in the substrate-binding centre to achieve their exquisite specificity. It is widely believed that substrate recognition by such enzymes involves a series of conformational changes in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737139/ https://www.ncbi.nlm.nih.gov/pubmed/26553802 http://dx.doi.org/10.1093/nar/gkv1092 |