Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway

We present evidence that Tim establishes a physical and functional interaction with DDX11, a super-family 2 iron-sulfur cluster DNA helicase genetically linked to the chromosomal instability disorder Warsaw breakage syndrome. Tim stimulates DDX11 unwinding activity on forked DNA substrates up to 10-...

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Detalles Bibliográficos
Autores principales: Calì, Federica, Bharti, Sanjay Kumar, Perna, Roberta Di, Brosh, Robert M., Pisani, Francesca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737141/
https://www.ncbi.nlm.nih.gov/pubmed/26503245
http://dx.doi.org/10.1093/nar/gkv1112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737141/
https://www.ncbi.nlm.nih.gov/pubmed/26503245
http://dx.doi.org/10.1093/nar/gkv1112

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