The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation

Highly transcribed guanine-run containing sequences, in Saccharomyces cerevisiae, become unstable when topoisomerase I (Top1) is disrupted. Topological changes, such as the formation of extended RNA:DNA hybrids or R-loops or non-canonical DNA structures including G-quadruplexes has been proposed as...

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Detalles Bibliográficos
Autores principales: Yadav, Puja, Owiti, Norah, Kim, Nayun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737143/
https://www.ncbi.nlm.nih.gov/pubmed/26527723
http://dx.doi.org/10.1093/nar/gkv1152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737143/
https://www.ncbi.nlm.nih.gov/pubmed/26527723
http://dx.doi.org/10.1093/nar/gkv1152

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