Cargando…

The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation

Highly transcribed guanine-run containing sequences, in Saccharomyces cerevisiae, become unstable when topoisomerase I (Top1) is disrupted. Topological changes, such as the formation of extended RNA:DNA hybrids or R-loops or non-canonical DNA structures including G-quadruplexes has been proposed as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yadav, Puja, Owiti, Norah, Kim, Nayun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737143/ https://www.ncbi.nlm.nih.gov/pubmed/26527723 http://dx.doi.org/10.1093/nar/gkv1152

Ejemplares similares

Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter
por: Cho, Jang-Eun, et al.
Publicado: (2015)

Ultraviolet-induced RNA:DNA hybrids interfere with chromosomal DNA synthesis
por: Kouzminova, Elena A, et al.
Publicado: (2021)

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis
por: Maskey, Reeja S., et al.
Publicado: (2017)

Elongating RNA polymerase II and RNA:DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions
por: Zardoni, Luca, et al.
Publicado: (2021)

Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA
por: Lopez, Christopher R., et al.
Publicado: (2017)

Genome-wide mapping of 8-oxo-7,8-dihydro-2′-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells
por: Amente, Stefano, et al.
Publicado: (2019)

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases δ and η
por: McCulloch, Scott D., et al.
Publicado: (2009)

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA
por: Rosa, Ilaria Dalla, et al.
Publicado: (2009)

Condensin aids sister chromatid decatenation by topoisomerase II
por: Charbin, Adrian, et al.
Publicado: (2014)

FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells
por: Pentzold, Constanze, et al.
Publicado: (2018)

Recovery of protein synthesis to assay DNA repair activity in transcribed genes in living cells and tissues
por: van der Woude, Melanie, et al.
Publicado: (2023)

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
por: Zhou, Jia, et al.
Publicado: (2015)

The MukB-topoisomerase IV interaction mutually suppresses their catalytic activities
por: Kumar, Rupesh, et al.
Publicado: (2021)

Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand
por: Reis, António M. C., et al.
Publicado: (2012)

Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation
por: Ren, Xiaolin, et al.
Publicado: (2010)

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells
por: Farr, Christine J., et al.
Publicado: (2014)

Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks
por: Szlachta, Karol, et al.
Publicado: (2020)

Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells
por: Guo, Jia, et al.
Publicado: (2013)

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression
por: Ramamoorthy, Mahesh, et al.
Publicado: (2012)

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
por: Das, Benu Brata, et al.
Publicado: (2014)

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions
por: Bilkis, Rabeya, et al.
Publicado: (2023)

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
por: Zeng, Zhihong, et al.
Publicado: (2012)

Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage
por: Rao, Timsi, et al.
Publicado: (2016)

PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes
por: Rehman, Ishita, et al.
Publicado: (2018)

Adenine versus guanine DNA adducts of aristolochic acids: role of the carcinogen–purine linkage in the differential global genomic repair propensity
por: Kathuria, Preetleen, et al.
Publicado: (2015)

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines
por: Degtyareva, Natalya P., et al.
Publicado: (2013)

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts
por: Gaggioli, Vincent, et al.
Publicado: (2013)

Structural, energetic and dynamic properties of guanine(C8)–thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair
por: Ding, Shuang, et al.
Publicado: (2012)

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase
por: Cerritelli, Susana M, et al.
Publicado: (2020)

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
por: Olmedo-Pelayo, Joaquín, et al.
Publicado: (2020)

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway
por: Paquet, Nicolas, et al.
Publicado: (2015)

Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity
por: Sproviero, Michael, et al.
Publicado: (2014)

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
por: Zhang, Yong-Wei, et al.
Publicado: (2011)

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions
por: Cristini, Agnese, et al.
Publicado: (2016)

The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline
por: Dello Stritto, Maria Rosaria, et al.
Publicado: (2022)

Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies
por: Mu, Hong, et al.
Publicado: (2012)

PRL-3 promotes telomere deprotection and chromosomal instability
por: Lian, Shenyi, et al.
Publicado: (2017)

Separase prevents genomic instability by controlling replication fork speed
por: Cucco, Francesco, et al.
Publicado: (2018)

VID22 counteracts G-quadruplex-induced genome instability
por: Galati, Elena, et al.
Publicado: (2021)

Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci
por: Kines, Kristine J., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_aidc988odv7h5r48mn6sn7pc5o