Cargando…
KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units
Mutations of the KRAS proto-oncogene are associated with several tumor types, which is why it is being considered as a target for anti-cancer drug development. The human KRAS promoter contains a nuclease hypersensitive element (NHE), which can bind to nuclear proteins and is believed to form G-quadr...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737153/ https://www.ncbi.nlm.nih.gov/pubmed/26656490 http://dx.doi.org/10.1093/nar/gkv1359 |