Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding

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Mixed duplex/quadruplex oligonucleotides have attracted great interest as therapeutic targets as well as effective biomedical aptamers. In the case of thrombin-binding aptamer (TBA), the addition of a duplex motif to the G-quadruplex module improves the aptamer resistance to biodegradation and the a...

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Detalles Bibliográficos
Autores principales: Russo Krauss, Irene, Spiridonova, Vera, Pica, Andrea, Napolitano, Valeria, Sica, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737158/
https://www.ncbi.nlm.nih.gov/pubmed/26673709
http://dx.doi.org/10.1093/nar/gkv1384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737158/
https://www.ncbi.nlm.nih.gov/pubmed/26673709
http://dx.doi.org/10.1093/nar/gkv1384

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