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Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
Mixed duplex/quadruplex oligonucleotides have attracted great interest as therapeutic targets as well as effective biomedical aptamers. In the case of thrombin-binding aptamer (TBA), the addition of a duplex motif to the G-quadruplex module improves the aptamer resistance to biodegradation and the a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737158/ https://www.ncbi.nlm.nih.gov/pubmed/26673709 http://dx.doi.org/10.1093/nar/gkv1384 |
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