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Probing binding hot spots at protein–RNA recognition sites

We use evolutionary conservation derived from structure alignment of polypeptide sequences along with structural and physicochemical attributes of protein–RNA interfaces to probe the binding hot spots at protein–RNA recognition sites. We find that the degree of conservation varies across the RNA bin...

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Detalles Bibliográficos
Autores principales: Barik, Amita, Nithin, Chandran, Karampudi, Naga Bhushana Rao, Mukherjee, Sunandan, Bahadur, Ranjit Prasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737170/
https://www.ncbi.nlm.nih.gov/pubmed/26365245
http://dx.doi.org/10.1093/nar/gkv876