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Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation

Primary cilia are single non‐motile organelles that provide a highly regulated compartment into which specific proteins are trafficked as a critical part of various signaling pathways. The absence of primary cilia has been shown to prevent differentiation of human mesenchymal stem cells (hMSCs). Cha...

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Detalles Bibliográficos
Autores principales: Dalbay, Melis T., Thorpe, Stephen D., Connelly, John T., Chapple, J. Paul, Knight, Martin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737234/
https://www.ncbi.nlm.nih.gov/pubmed/25693948
http://dx.doi.org/10.1002/stem.1975