Cargando…

Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation

Genome-wide association studies have successfully identified thousands of loci for a range of human complex traits and diseases. The proportion of phenotypic variance explained by significant associations is, however, limited. Given the same dense SNP panels, mixed model analyses capture a greater p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Charley, Amador, Carmen, Huffman, Jennifer, Trochet, Holly, Campbell, Archie, Porteous, David, Hastie, Nicholas D., Hayward, Caroline, Vitart, Veronique, Navarro, Pau, Haley, Chris S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737500/ https://www.ncbi.nlm.nih.gov/pubmed/26836320 http://dx.doi.org/10.1371/journal.pgen.1005804

Ejemplares similares

Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation
por: Xia, Charley, et al.
Publicado: (2017)

Recent genomic heritage in Scotland
por: Amador, Carmen, et al.
Publicado: (2015)

Regional variation in health is predominantly driven by lifestyle rather than genetics
por: Amador, Carmen, et al.
Publicado: (2017)

Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression
por: Zeng, Yanni, et al.
Publicado: (2016)

SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): Joint Mapping of Common and Rare Variation Affecting Complex Traits
por: Oppong, Richard F., et al.
Publicado: (2022)

Uncovering Networks from Genome-Wide Association Studies via Circular Genomic Permutation
por: Cabrera, Claudia P., et al.
Publicado: (2012)

Genetic parameters for periodontal disease: an analysis of electronic dental treatment records linked to pedigree, genomic, sociodemographic and clinical data
por: Bermingham, Mairead, et al.
Publicado: (2017)

Electronic health record and genome-wide genetic data in Generation Scotland participants
por: Kerr, Shona M., et al.
Publicado: (2017)

The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits
por: Uemoto, Yoshinobu, et al.
Publicado: (2013)

Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
por: Nagy, Reka, et al.
Publicado: (2017)

The genetic landscape of Scotland and the Isles
por: Gilbert, Edmund, et al.
Publicado: (2019)

Genetic Comparison of a Croatian Isolate and CEPH European Founders
por: Navarro, Pau, et al.
Publicado: (2010)

Genome-wide methylation data improves dissection of the effect of smoking on body mass index
por: Amador, Carmen, et al.
Publicado: (2021)

Local Exome Sequences Facilitate Imputation of Less Common Variants and Increase Power of Genome Wide Association Studies
por: Joshi, Peter K., et al.
Publicado: (2013)

Localising Loci underlying Complex Trait Variation Using Regional Genomic Relationship Mapping
por: Nagamine, Yoshitaka, et al.
Publicado: (2012)

Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study
por: Kerr, Shona M, et al.
Publicado: (2013)

Identification of Mendelian inconsistencies between SNP and pedigree information of sibs
por: Calus, Mario PL, et al.
Publicado: (2011)

Genomic analysis of family data reveals additional genetic effects on intelligence and personality
por: Hill, W. David, et al.
Publicado: (2018)

Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?
por: Arnold, Amy C., et al.
Publicado: (2015)

Characterisation of Genome-Wide Association Epistasis Signals for Serum Uric Acid in Human Population Isolates
por: Wei, Wenhua, et al.
Publicado: (2011)

Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models
por: Spiliopoulou, Athina, et al.
Publicado: (2015)

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism
por: Clarke, Toni-Kim, et al.
Publicado: (2019)

Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations
por: Shirali, M, et al.
Publicado: (2016)

Genome-wide analysis of epistasis in body mass index using multiple human populations
por: Wei, Wen-Hua, et al.
Publicado: (2012)

Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set
por: Howard, Nicholas P, et al.
Publicado: (2017)

Power of a dual‐use SNP panel for pedigree reconstruction and population assignment
por: May, Samuel A., et al.
Publicado: (2020)

Pedigree reconstruction from SNP data: parentage assignment, sibship clustering and beyond
por: Huisman, Jisca
Publicado: (2017)

Elevated Erythritol: A Marker of Metabolic Dysregulation or Contributor to the Pathogenesis of Cardiometabolic Disease?
por: Mazi, Tagreed A., et al.
Publicado: (2023)

Phenome-wide analysis identifies parent-of-origin effects on the human methylome associated with changes in the rate of aging
por: Gao, Chenhao, et al.
Publicado: (2023)

Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans
por: Gao, Chenhao, et al.
Publicado: (2023)

Insights into the genetic basis of retinal detachment
por: Boutin, Thibaud S, et al.
Publicado: (2020)

A New Pedigree-Based SNP Haplotype Method for Genomic Polymorphism and Genetic Studies
por: Vadva, Zareen, et al.
Publicado: (2019)

Assessment of the Genetic Diversity of a Local Pig Breed Using Pedigree and SNP Data
por: Krupa, Emil, et al.
Publicado: (2021)

Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
por: Zeng, Yanni, et al.
Publicado: (2019)

Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
por: Zeng, Yanni, et al.
Publicado: (2019)

Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data
por: Powell, Joseph E., et al.
Publicado: (2013)

SNP Analysis and Whole Exome Sequencing: Their Application in the Analysis of a Consanguineous Pedigree Segregating Ataxia
por: Nickerson, Sarah L., et al.
Publicado: (2015)

Heritability estimates of distichiasis in Staffordshire bull terriers using pedigrees and genome-wide SNP data
por: Joergensen, Dina, et al.
Publicado: (2022)

Anthropometric and cardiometabolic risk factors in parents and child obesity in Segamat, Malaysia
por: Partap, Uttara, et al.
Publicado: (2017)

Obesity anthropometric indicators associated with cardiometabolic risk in Portuguese children and adolescents
por: Gaya, Anelise Reis, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_geipt2n6dadqdarbh8lgiab3rh