Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Mulay, Shrikant R., Desai, Jyaysi, Kumar, Santhosh V., Eberhard, Jonathan N., Thomasova, Dana, Romoli, Simone, Grigorescu, Melissa, Kulkarni, Onkar P., Popper, Bastian, Vielhauer, Volker, Zuchtriegel, Gabriele, Reichel, Christoph, Bräsen, Jan Hinrich, Romagnani, Paola, Bilyy, Rostyslav, Munoz, Luis E., Herrmann, Martin, Liapis, Helen, Krautwald, Stefan, Linkermann, Andreas, Anders, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738349/
https://www.ncbi.nlm.nih.gov/pubmed/26817517
http://dx.doi.org/10.1038/ncomms10274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738349/
https://www.ncbi.nlm.nih.gov/pubmed/26817517
http://dx.doi.org/10.1038/ncomms10274

Ejemplares similares