A mouse model for a partially inactive obesity-associated human MC3R variant

We previously reported children homozygous for two MC3R sequence variants (C17A+G241A) have greater fat mass than controls. Here we show, using homozygous knock-in mouse models in which we replace murine Mc3r with wild-type human (MC3R(hWT/hWT)) and double-mutant (C17A+G241A) human (MC3R(hDM/hDM)) M...

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Detalles Bibliográficos
Autores principales: Lee, Bonggi, Koo, Jashin, Yun Jun, Joo, Gavrilova, Oksana, Lee, Yongjun, Seo, Arnold Y., Taylor-Douglas, Dezmond C., Adler-Wailes, Diane C., Chen, Faye, Gardner, Ryan, Koutzoumis, Dimitri, Sherafat Kazemzadeh, Roya, Roberson, Robin B., Yanovski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738366/
https://www.ncbi.nlm.nih.gov/pubmed/26818770
http://dx.doi.org/10.1038/ncomms10522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738366/
https://www.ncbi.nlm.nih.gov/pubmed/26818770
http://dx.doi.org/10.1038/ncomms10522

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