Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice

Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease. We utilized apoE4‐targeted replacement mice (approved by the Tel Aviv University Animal Care Committee) to investigate whether cholinergic dysfunction, which increases during aging and is a hallmark of...

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Detalles Bibliográficos
Autores principales: Dolejší, Eva, Liraz, Ori, Rudajev, Vladimír, Zimčík, Pavel, Doležal, Vladimír, Michaelson, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738402/
https://www.ncbi.nlm.nih.gov/pubmed/26526158
http://dx.doi.org/10.1111/jnc.13417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738402/
https://www.ncbi.nlm.nih.gov/pubmed/26526158
http://dx.doi.org/10.1111/jnc.13417

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