Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging

Exosome trafficking from the placenta into the maternal circulation is well documented; the possibility that this trafficking is bi‐directional was unknown. We demonstrated clathrin‐mediated endocytosis of macrophage exosomes by the human placenta. We also demonstrated that macrophage exosomes induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Holder, Beth, Jones, Tessa, Sancho Shimizu, Vanessa, Rice, Thomas F., Donaldson, Beverly, Bouqueau, Marielle, Forbes, Karen, Kampmann, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738478/
https://www.ncbi.nlm.nih.gov/pubmed/26602702
http://dx.doi.org/10.1111/tra.12352
_version_ 1782413619848282112
author Holder, Beth
Jones, Tessa
Sancho Shimizu, Vanessa
Rice, Thomas F.
Donaldson, Beverly
Bouqueau, Marielle
Forbes, Karen
Kampmann, Beate
author_facet Holder, Beth
Jones, Tessa
Sancho Shimizu, Vanessa
Rice, Thomas F.
Donaldson, Beverly
Bouqueau, Marielle
Forbes, Karen
Kampmann, Beate
author_sort Holder, Beth
collection PubMed
description Exosome trafficking from the placenta into the maternal circulation is well documented; the possibility that this trafficking is bi‐directional was unknown. We demonstrated clathrin‐mediated endocytosis of macrophage exosomes by the human placenta. We also demonstrated that macrophage exosomes induced placental production of cytokines interleukin (IL)‐6, IL‐8 and IL‐10. Exosomes therefore comprise an additional mechanism of immune cell signalling to the placenta, potentially facilitating protective responses to maternal inflammation and infection in pregnancy. This represents a novel mode of maternal–placental messaging. [Image: see text]
format Online
Article
Text
id pubmed-4738478
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley & Sons A/S
record_format MEDLINE/PubMed
spelling pubmed-47384782016-02-12 Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging Holder, Beth Jones, Tessa Sancho Shimizu, Vanessa Rice, Thomas F. Donaldson, Beverly Bouqueau, Marielle Forbes, Karen Kampmann, Beate Traffic Original Articles Exosome trafficking from the placenta into the maternal circulation is well documented; the possibility that this trafficking is bi‐directional was unknown. We demonstrated clathrin‐mediated endocytosis of macrophage exosomes by the human placenta. We also demonstrated that macrophage exosomes induced placental production of cytokines interleukin (IL)‐6, IL‐8 and IL‐10. Exosomes therefore comprise an additional mechanism of immune cell signalling to the placenta, potentially facilitating protective responses to maternal inflammation and infection in pregnancy. This represents a novel mode of maternal–placental messaging. [Image: see text] John Wiley & Sons A/S 2016-01-26 2016-02 /pmc/articles/PMC4738478/ /pubmed/26602702 http://dx.doi.org/10.1111/tra.12352 Text en © 2015 The Authors. Traffic published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Holder, Beth
Jones, Tessa
Sancho Shimizu, Vanessa
Rice, Thomas F.
Donaldson, Beverly
Bouqueau, Marielle
Forbes, Karen
Kampmann, Beate
Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
title Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
title_full Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
title_fullStr Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
title_full_unstemmed Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
title_short Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
title_sort macrophage exosomes induce placental inflammatory cytokines: a novel mode of maternal–placental messaging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738478/
https://www.ncbi.nlm.nih.gov/pubmed/26602702
http://dx.doi.org/10.1111/tra.12352
work_keys_str_mv AT holderbeth macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT jonestessa macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT sanchoshimizuvanessa macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT ricethomasf macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT donaldsonbeverly macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT bouqueaumarielle macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT forbeskaren macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging
AT kampmannbeate macrophageexosomesinduceplacentalinflammatorycytokinesanovelmodeofmaternalplacentalmessaging

Ejemplares similares