Aurora kinase targeting in lung cancer reduces KRAS-induced transformation

BACKGROUND: Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification of KRAS targets that impinge on the oncogenic phenotype is warranted. Based on p...

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Detalles Bibliográficos
Autores principales: dos Santos, Edmilson Ozorio, Carneiro-Lobo, Tatiana Correa, Aoki, Mateus Nobrega, Levantini, Elena, Bassères, Daniela Sanchez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739397/
https://www.ncbi.nlm.nih.gov/pubmed/26842935
http://dx.doi.org/10.1186/s12943-016-0494-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739397/
https://www.ncbi.nlm.nih.gov/pubmed/26842935
http://dx.doi.org/10.1186/s12943-016-0494-6

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