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Aurora kinase targeting in lung cancer reduces KRAS-induced transformation
BACKGROUND: Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification of KRAS targets that impinge on the oncogenic phenotype is warranted. Based on p...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739397/ https://www.ncbi.nlm.nih.gov/pubmed/26842935 http://dx.doi.org/10.1186/s12943-016-0494-6 |