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The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium
Epithelial morphogenesis and stability are essential for normal development and organ homeostasis. The mouse neural plate is a cuboidal epithelium that remodels into a columnar pseudostratified epithelium over the course of 24 hr. Here we show that the transition to a columnar epithelium fails in mu...
Autores principales: | Grego-Bessa, Joaquim, Bloomekatz, Joshua, Castel, Pau, Omelchenko, Tatiana, Baselga, José, Anderson, Kathryn V |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739759/ https://www.ncbi.nlm.nih.gov/pubmed/26809587 http://dx.doi.org/10.7554/eLife.12034 |
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