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Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon, consistent with kinesin-1 driving outgrowth by...

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Detalles Bibliográficos
Autores principales: del Castillo, Urko, Winding, Michael, Lu, Wen, Gelfand, Vladimir I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739764/
https://www.ncbi.nlm.nih.gov/pubmed/26615019
http://dx.doi.org/10.7554/eLife.10140