ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences and reflect tumor microenvironment. By i...

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Detalles Bibliográficos
Autores principales: Yang, Hanseul, Schramek, Daniel, Adam, Rene C, Keyes, Brice E, Wang, Ping, Zheng, Deyou, Fuchs, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739765/
https://www.ncbi.nlm.nih.gov/pubmed/26590320
http://dx.doi.org/10.7554/eLife.10870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739765/
https://www.ncbi.nlm.nih.gov/pubmed/26590320
http://dx.doi.org/10.7554/eLife.10870

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