A Novel Histone Deacetylase Inhibitor, AR-42, Reactivates HIV-1 from Chronically and Latently Infected CD4(+) T-cells

Human immunodeficiency virus type 1 (HIV-1) latency is a major barrier to a cure of AIDS. Latently infected cells harbor an integrated HIV-1 genome but are not actively producing HIV-1. Histone deacetylase (HDAC) inhibitors, such as vorinostat (SAHA), have been shown to reactivate latent HIV-1. AR-4...

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Detalles Bibliográficos
Autores principales: Mates, Jessica M., de Silva, Suresh, Lustberg, Mark, Van Deusen, Kelsey, Baiocchi, Robert A., Wu, Li, Kwiek, Jesse J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739806/
https://www.ncbi.nlm.nih.gov/pubmed/26855567
http://dx.doi.org/10.4137/RRT.S31632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739806/
https://www.ncbi.nlm.nih.gov/pubmed/26855567
http://dx.doi.org/10.4137/RRT.S31632

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