Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Mutations in the transcriptional regulator Mecp2 cause the severe X-linked neurodevelopmental disorder Rett syndrome (RTT). In this study, we investigate genes that function downstream of MeCP2 in cerebral cortex circuitry, and identify upregulation of Irak1, a central component of the NF-κB pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Kishi, Noriyuki, MacDonald, Jessica L., Ye, Julia, Molyneaux, Bradley J., Azim, Eiman, Macklis, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740176/
https://www.ncbi.nlm.nih.gov/pubmed/26821816
http://dx.doi.org/10.1038/ncomms10520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740176/
https://www.ncbi.nlm.nih.gov/pubmed/26821816
http://dx.doi.org/10.1038/ncomms10520

Ejemplares similares