Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

The levels, regulation and prognostic value of p21 in head and neck squamous cell carcinomas (HNSCC) has been puzzling for years. Here, we report a new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway. We find that non-phosphorylated 4E-BP1 interacts with p21 and induces its degradation....

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Detalles Bibliográficos
Autores principales: Llanos, Susana, García-Pedrero, Juana M., Morgado-Palacin, Lucia, Rodrigo, Juan P., Serrano, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740818/
https://www.ncbi.nlm.nih.gov/pubmed/26832959
http://dx.doi.org/10.1038/ncomms10438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740818/
https://www.ncbi.nlm.nih.gov/pubmed/26832959
http://dx.doi.org/10.1038/ncomms10438

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