RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

XRCC4-like factor (XLF) functions in classical non-homologous end-joining (cNHEJ) but is dispensable for the repair of DNA double-strand breaks (DSBs) generated during V(D)J recombination. A long-standing hypothesis proposes that, in addition to its canonical nuclease activity, the RAG1/2 proteins p...

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Detalles Bibliográficos
Autores principales: Lescale, Chloé, Abramowski, Vincent, Bedora-Faure, Marie, Murigneux, Valentine, Vera, Gabriella, Roth, David B., Revy, Patrick, de Villartay, Jean-Pierre, Deriano, Ludovic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740868/
https://www.ncbi.nlm.nih.gov/pubmed/26833222
http://dx.doi.org/10.1038/ncomms10529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740868/
https://www.ncbi.nlm.nih.gov/pubmed/26833222
http://dx.doi.org/10.1038/ncomms10529

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