Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a post-translational modification first discovered in 1980, plays a critical role in diverse nuclear processes including the regulation of transcription and DNA damage repair. Herein, we use a suite of protein chemistry methods to explore how H2B...

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Detalles Bibliográficos
Autores principales: Zhou, Linjiao, Holt, Matthew T., Ohashi, Nami, Zhao, Aishan, Müller, Manuel M., Wang, Boyuan, Muir, Tom W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740876/
https://www.ncbi.nlm.nih.gov/pubmed/26830124
http://dx.doi.org/10.1038/ncomms10589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740876/
https://www.ncbi.nlm.nih.gov/pubmed/26830124
http://dx.doi.org/10.1038/ncomms10589

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