Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation

Tumour suppressor miR-34c deficiency resulted from hyper-methylation in its promoter is believed to be one of the main causes of colorectal cancer (CRC). Till date, miR-34c has been validated as a direct target of p53; but previous evidence suggested other transcription factor(s) must be involved in...

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Detalles Bibliográficos
Autores principales: Yang, Shu, Wu, Bo, Sun, Haimei, Ji, Fengqing, Sun, Tingyi, Zhao, Yan, Zhou, Deshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741184/
https://www.ncbi.nlm.nih.gov/pubmed/26704889
http://dx.doi.org/10.1042/BSR20150290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741184/
https://www.ncbi.nlm.nih.gov/pubmed/26704889
http://dx.doi.org/10.1042/BSR20150290

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