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Arenobufagin intercalates with DNA leading to G(2) cell cycle arrest via ATM/ATR pathway
Arenobufagin, a representative bufadienolide, is the major active component in the traditional Chinese medicine Chan'su. It possesses significant antineoplastic activity in vitro. Although bufadienolide has been found to disrupt the cell cycle, the underlying mechanisms of this disruption are n...
Autores principales: | Deng, Li-Juan, Peng, Qun-Long, Wang, Long-Hai, Xu, Jun, Liu, Jun-Shan, Li, Ying-Jie, Zhuo, Zhen-Jian, Bai, Liang-Liang, Hu, Li-Ping, Chen, Wei-Min, Ye, Wen-Cai, Zhang, Dong-Mei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741450/ https://www.ncbi.nlm.nih.gov/pubmed/26485758 |
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