Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer

The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and...

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Detalles Bibliográficos
Autores principales: Yu, Yue, Zhao, Ying, Sun, Xiao-Hu, Ge, Jie, Zhang, Bin, Wang, Xin, Cao, Xu-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741463/
https://www.ncbi.nlm.nih.gov/pubmed/26460733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741463/
https://www.ncbi.nlm.nih.gov/pubmed/26460733

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