Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer

The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Yue, Zhao, Ying, Sun, Xiao-Hu, Ge, Jie, Zhang, Bin, Wang, Xin, Cao, Xu-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741463/
https://www.ncbi.nlm.nih.gov/pubmed/26460733
_version_ 1782413996883705856
author Yu, Yue
Zhao, Ying
Sun, Xiao-Hu
Ge, Jie
Zhang, Bin
Wang, Xin
Cao, Xu-Chen
author_facet Yu, Yue
Zhao, Ying
Sun, Xiao-Hu
Ge, Jie
Zhang, Bin
Wang, Xin
Cao, Xu-Chen
author_sort Yu, Yue
collection PubMed
description The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and Snail transcriptionally suppressed miR-129-5p expression. Levels of miR-129-5p were low in breast cancer tissues. miR-129-5p down-regulation correlated with advanced clinical stage and poor prognosis in patients with breast cancer. miR-129-5p expression negatively correlated with Twist1 and Snail expression. Thus, miR-129-5p down-regulation fosters EMT in breast cancer by increasing Twist1-Snail and activating a negative feedback loop.
format Online
Article
Text
id pubmed-4741463
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-47414632016-03-15 Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer Yu, Yue Zhao, Ying Sun, Xiao-Hu Ge, Jie Zhang, Bin Wang, Xin Cao, Xu-Chen Oncotarget Research Paper The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and Snail transcriptionally suppressed miR-129-5p expression. Levels of miR-129-5p were low in breast cancer tissues. miR-129-5p down-regulation correlated with advanced clinical stage and poor prognosis in patients with breast cancer. miR-129-5p expression negatively correlated with Twist1 and Snail expression. Thus, miR-129-5p down-regulation fosters EMT in breast cancer by increasing Twist1-Snail and activating a negative feedback loop. Impact Journals LLC 2015-10-07 /pmc/articles/PMC4741463/ /pubmed/26460733 Text en Copyright: © 2015 Yu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yu, Yue
Zhao, Ying
Sun, Xiao-Hu
Ge, Jie
Zhang, Bin
Wang, Xin
Cao, Xu-Chen
Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
title Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
title_full Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
title_fullStr Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
title_full_unstemmed Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
title_short Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
title_sort down-regulation of mir-129-5p via the twist1-snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741463/
https://www.ncbi.nlm.nih.gov/pubmed/26460733
work_keys_str_mv AT yuyue downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer
AT zhaoying downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer
AT sunxiaohu downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer
AT gejie downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer
AT zhangbin downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer
AT wangxin downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer
AT caoxuchen downregulationofmir1295pviathetwist1snailfeedbackloopstimulatestheepithelialmesenchymaltransitionandisassociatedwithpoorprognosisinbreastcancer

Ejemplares similares