Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death

A single nucleotide polymorphism (T to G) in the mdm2 P2 promoter, mdm2 SNP309, leads to MDM2 overexpression promoting chemotherapy resistant cancers. Two mdm2 G/G SNP309 cancer cell lines, MANCA and A875, have compromised wild-type p53 that co-localizes with MDM2 on chromatin. We hypothesized that...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosso, Melissa, Polotskaia, Alla, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741474/
https://www.ncbi.nlm.nih.gov/pubmed/26416444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741474/
https://www.ncbi.nlm.nih.gov/pubmed/26416444

Ejemplares similares