A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth

Utility of traditional oncolytic adenovirus (Ad) has been limited due to low expression of coxsackie and adenovirus receptor (CAR) in cancer cells which results in poor infectivity of Ads. Here with an aim of improving the efficiency of Ad's entry to the cell, we generated a novel tropism-expan...

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Detalles Bibliográficos
Autores principales: Yoon, A-Rum, Hong, Jinwoo, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741496/
https://www.ncbi.nlm.nih.gov/pubmed/26430798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741496/
https://www.ncbi.nlm.nih.gov/pubmed/26430798

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