Unbiased Rare Event Sampling in Spatial Stochastic Systems Biology Models Using a Weighted Ensemble of Trajectories

The long-term goal of connecting scales in biological simulation can be facilitated by scale-agnostic methods. We demonstrate that the weighted ensemble (WE) strategy, initially developed for molecular simulations, applies effectively to spatially resolved cell-scale simulations. The WE approach run...

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Detalles Bibliográficos
Autores principales: Donovan, Rory M., Tapia, Jose-Juan, Sullivan, Devin P., Faeder, James R., Murphy, Robert F., Dittrich, Markus, Zuckerman, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741515/
https://www.ncbi.nlm.nih.gov/pubmed/26845334
http://dx.doi.org/10.1371/journal.pcbi.1004611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741515/
https://www.ncbi.nlm.nih.gov/pubmed/26845334
http://dx.doi.org/10.1371/journal.pcbi.1004611

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