sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways

The suppressor of MEK null (sMEK1) protein possesses pro-apoptotic activities. In the current study, we reveal that sMEK1 functions as a novel anti-angiogenic factor by suppressing vascular endothelial growth factor (VEGF)-induced cell proliferation, migration, and capillary-like tubular structure i...

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Detalles Bibliográficos
Autores principales: Kim, Boh-Ram, Seo, Seung Hee, Park, Mi Sun, Lee, Seung-Hoon, Kwon, Youngjoo, Rho, Seung Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741643/
https://www.ncbi.nlm.nih.gov/pubmed/26378810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741643/
https://www.ncbi.nlm.nih.gov/pubmed/26378810

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