Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia

Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent this clinical problem. Here we analyzed the activ...

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Detalles Bibliográficos
Autores principales: Iacovelli, Stefano, Ricciardi, Maria Rosaria, Allegretti, Matteo, Mirabilii, Simone, Licchetta, Roberto, Bergamo, Paola, Rinaldo, Cinzia, Zeuner, Ann, Foà, Robin, Milella, Michele, McCubrey, James A., Martelli, Alberto M., Tafuri, Agostino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741661/
https://www.ncbi.nlm.nih.gov/pubmed/26392332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741661/
https://www.ncbi.nlm.nih.gov/pubmed/26392332

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