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Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia
Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent this clinical problem. Here we analyzed the activ...
Autores principales: | Iacovelli, Stefano, Ricciardi, Maria Rosaria, Allegretti, Matteo, Mirabilii, Simone, Licchetta, Roberto, Bergamo, Paola, Rinaldo, Cinzia, Zeuner, Ann, Foà, Robin, Milella, Michele, McCubrey, James A., Martelli, Alberto M., Tafuri, Agostino |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741661/ https://www.ncbi.nlm.nih.gov/pubmed/26392332 |
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