Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

Pharmacological inhibition of the cell cycle regulatory kinase Wee1 represents a promising strategy to eliminate cancer cells. Wee1 inhibitors cooperate with chemotherapeutics, e. g. nucleoside analogues, pushing malignant cells from S phase towards premature mitosis and death. However, considerable...

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Detalles Bibliográficos
Autores principales: Li, Yizhu, Saini, Priyanka, Sriraman, Anusha, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741697/
https://www.ncbi.nlm.nih.gov/pubmed/26431163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741697/
https://www.ncbi.nlm.nih.gov/pubmed/26431163

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