Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

ATRis an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibi...

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Detalles Bibliográficos
Autores principales: Middleton, Fiona K., Patterson, Miranda J., Elstob, Claire J., Fordham, Sarah, Herriott, Ashleigh, Wade, Mark A., McCormick, Aiste, Edmondson, Richard, May, Felicity E.B., Allan, James M., Pollard, John R., Curtin, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741701/
https://www.ncbi.nlm.nih.gov/pubmed/26486089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741701/
https://www.ncbi.nlm.nih.gov/pubmed/26486089

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