Cargando…

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

Metastatic pheochromocytomas and paragangliomas (PPGL) are malignant neuroendocrine tumors frequently associated with germline mutations in the SDHB gene. SDHB-mutated PPGL display a hypermethylator phenotype associated with hallmarks of epithelial-to-mesenchymal transition (EMT). In the present stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loriot, Céline, Domingues, Mélanie, Berger, Adeline, Menara, Mélanie, Ruel, Maëva, Morin, Aurélie, Castro-Vega, Luis-Jaime, Letouzé, Éric, Martinelli, Cosimo, Bemelmans, Alexis-Pierre, Larue, Lionel, Gimenez-Roqueplo, Anne-Paule, Favier, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741742/ https://www.ncbi.nlm.nih.gov/pubmed/26460615

Ejemplares similares

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
por: Lussey-Lepoutre, Charlotte, et al.
Publicado: (2015)

Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas
por: Castro-Vega, Luis Jaime, et al.
Publicado: (2015)

International initiative for a curated SDHB variant database improving the diagnosis of hereditary paraganglioma and pheochromocytoma
por: Ben Aim, Laurene, et al.
Publicado: (2022)

Mitochondrial Deficiencies in the Predisposition to Paraganglioma
por: Lussey-Lepoutre, Charlotte, et al.
Publicado: (2017)

Quantifying evidence toward pathogenicity for rare phenotypes: The case of succinate dehydrogenase genes, SDHB and SDHD
por: Garrett, Alice, et al.
Publicado: (2022)

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
por: Bénit, Paule, et al.
Publicado: (2022)

Identity by Descent Mapping of Founder Mutations in Cancer Using High-Resolution Tumor SNP Data
por: Letouzé, Eric, et al.
Publicado: (2012)

Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report
por: Ugarte-Camara, Marina, et al.
Publicado: (2019)

Rapid determination of tricarboxylic acid cycle enzyme activities in biological samples
por: Goncalves, Sergio, et al.
Publicado: (2010)

SDHB and SDHA Immunohistochemistry in Canine Pheochromocytomas
por: Abed, Firas M., et al.
Publicado: (2020)

Pheochromocytomas and secreting paragangliomas
por: Plouin, Pierre-François, et al.
Publicado: (2006)

SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas
por: Armstrong, Neali, et al.
Publicado: (2022)

Pituitary Carcinoma in a Patient with an SDHB Mutation
por: Tufton, Nicola, et al.
Publicado: (2017)

Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
por: Bénit, Paule, et al.
Publicado: (2019)

Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma
por: Astuti, D, et al.
Publicado: (2004)

Germline SDHB and SDHD mutations in pheochromocytoma and paraganglioma patients
por: Huang, Yiqiang, et al.
Publicado: (2018)

Four generations of SDHB-related disease: complexities in management
por: Srirangalingam, U., et al.
Publicado: (2016)

Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers
por: Rijken, Johannes A., et al.
Publicado: (2019)

Efficacy of Immunohistochemistry for SDHB in the Screening of Hereditary Pheochromocytoma–Paraganglioma
por: Choi, Hye-Ryeon, et al.
Publicado: (2021)

Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity
por: Domingues, Mélanie J., et al.
Publicado: (2017)

Update on the genetics of paragangliomas
por: Gimenez-Roqueplo, Anne-Paule, et al.
Publicado: (2023)

Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists
por: Wang, Jeanny H., et al.
Publicado: (2011)

Identification of a novel SDHB c.563 T > C mutation responsible for Paraganglioma syndrome and genetic analysis of the SDHB gene in China: a case report
por: Chen, Heye, et al.
Publicado: (2020)

The first Dutch SDHB founder deletion in paraganglioma – pheochromocytoma patients
por: Bayley, Jean-Pierre, et al.
Publicado: (2009)

Use of SDHB immunohistochemistry to identify germline mutations of SDH genes
por: Gill, AJ
Publicado: (2012)

An analysis of surveillance screening for SDHB-related disease in childhood and adolescence
por: Tufton, Nicola, et al.
Publicado: (2019)

Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas
por: Sarkadi, Balazs, et al.
Publicado: (2020)

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting Glycolysis
por: Fang, Zhiyu, et al.
Publicado: (2021)

Rapid Detection of SdhB(P225F) and SdhB(H272R) Mutations in Boscalid Resistant Botrytis cinerea Strains by ARMS-PCR
por: Liu, Xin, et al.
Publicado: (2019)

Overexpression of miR‐483‐5p is confined to metastases and linked to high circulating levels in patients with metastatic pheochromocytoma/paraganglioma
por: Castro‐Vega, Luis Jaime, et al.
Publicado: (2020)

Calculating the optimal surveillance for head and neck paraganglioma in SDHB-mutation carriers
por: Eijkelenkamp, Karin, et al.
Publicado: (2016)

Paraganglioma of the tongue with SDHB gene mutation in a patient with Graves’ disease
por: Duran Alvarez, Marcela Adriana, et al.
Publicado: (2019)

A Multifocal Paraganglioma in an African Male Due to an Underlying SDHB Mutation
por: Siddiqui, Nida Mishraz, et al.
Publicado: (2021)

SDHB immunohistochemistry for prognosis of pheochromocytoma and paraganglioma: A retrospective and prospective analysis
por: Su, Tingwei, et al.
Publicado: (2023)

Genetic testing and immunohistochemistry for SDHB in phaeochromocytoma-paraganglioma syndromes: the South Australian experience
por: Poplawski, NK, et al.
Publicado: (2012)

Low penetrance of a SDHB mutation in a large Dutch paraganglioma family
por: Hes, Frederik J, et al.
Publicado: (2010)

Hypoxia-inducible C-to-U coding RNA editing downregulates SDHB in monocytes
por: Baysal, Bora E., et al.
Publicado: (2013)

A patient with a germline SDHB mutation presenting with an isolated pituitary macroprolactinoma
por: Maher, Michelle, et al.
Publicado: (2018)

Nationwide study of patients with head and neck paragangliomas carrying SDHB germline mutations
por: Rijken, J. A., et al.
Publicado: (2018)

SUN-344 SDHB Immunostaining: Still an Indispensable Tool in Characterising Pheochromocytoma and Paraganglioma
por: Velusamy, Anand, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2ba5n4iodbd6no3shugl07dbv4