Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapA

Transcription factor NFAT1 has been recently identified as a new regulator of the MDM2 oncogene. Targeting the NFAT1-MDM2 pathway represents a novel approach to cancer therapy. We have recently identified a natural product MDM2 inhibitor, termed JapA. As a specific and potent MDM2 inhibitor, JapA in...

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Detalles Bibliográficos
Autores principales: Qin, Jiang-Jiang, Wang, Wei, Voruganti, Sukesh, Wang, Hui, Zhang, Wei-Dong, Zhang, Ruiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741752/
https://www.ncbi.nlm.nih.gov/pubmed/26461225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741752/
https://www.ncbi.nlm.nih.gov/pubmed/26461225

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