Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion

Golgi Protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC), however its role in HCC is not clear. We report that GP73 promotes cell invasion, the hallmark of malignancy, through the upregulation of matrix metalloproteinase-13 (MMP-13). GP73 enhances MMP-13 expression through cAM...

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Autores principales: Jin, Di, Tao, Jun, Li, Dan, Wang, Yanan, Li, Li, Hu, Zhongdong, Zhou, Zhenzhen, Chang, Xiuli, Qu, Chunfeng, Zhang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741783/
https://www.ncbi.nlm.nih.gov/pubmed/26378022
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author Jin, Di
Tao, Jun
Li, Dan
Wang, Yanan
Li, Li
Hu, Zhongdong
Zhou, Zhenzhen
Chang, Xiuli
Qu, Chunfeng
Zhang, Hongbing
author_facet Jin, Di
Tao, Jun
Li, Dan
Wang, Yanan
Li, Li
Hu, Zhongdong
Zhou, Zhenzhen
Chang, Xiuli
Qu, Chunfeng
Zhang, Hongbing
author_sort Jin, Di
collection PubMed
description Golgi Protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC), however its role in HCC is not clear. We report that GP73 promotes cell invasion, the hallmark of malignancy, through the upregulation of matrix metalloproteinase-13 (MMP-13). GP73 enhances MMP-13 expression through cAMP responsive element binding protein (CREB)-mediated transcription activation. Levels of GP73 and MMP-13 are increased and positively correlated in human HCC tissues. Augmented MMP-13 potentiates HCC cell metastasis. Thus, the GP73-CREB-MMP-13 axis potentiates cancer cell invasion and may be a target for HCC treatment.
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spelling pubmed-47417832016-03-11 Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion Jin, Di Tao, Jun Li, Dan Wang, Yanan Li, Li Hu, Zhongdong Zhou, Zhenzhen Chang, Xiuli Qu, Chunfeng Zhang, Hongbing Oncotarget Research Paper Golgi Protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC), however its role in HCC is not clear. We report that GP73 promotes cell invasion, the hallmark of malignancy, through the upregulation of matrix metalloproteinase-13 (MMP-13). GP73 enhances MMP-13 expression through cAMP responsive element binding protein (CREB)-mediated transcription activation. Levels of GP73 and MMP-13 are increased and positively correlated in human HCC tissues. Augmented MMP-13 potentiates HCC cell metastasis. Thus, the GP73-CREB-MMP-13 axis potentiates cancer cell invasion and may be a target for HCC treatment. Impact Journals LLC 2015-09-10 /pmc/articles/PMC4741783/ /pubmed/26378022 Text en Copyright: © 2015 Jin et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Jin, Di
Tao, Jun
Li, Dan
Wang, Yanan
Li, Li
Hu, Zhongdong
Zhou, Zhenzhen
Chang, Xiuli
Qu, Chunfeng
Zhang, Hongbing
Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion
title Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion
title_full Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion
title_fullStr Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion
title_full_unstemmed Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion
title_short Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion
title_sort golgi protein 73 activation of mmp-13 promotes hepatocellular carcinoma cell invasion
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741783/
https://www.ncbi.nlm.nih.gov/pubmed/26378022
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