LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neuroblastomas. Neuroblastoma is a clinically heterogenous...

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Detalles Bibliográficos
Autores principales: Vieira, Gabriella Cunha, Chockalingam, S., Melegh, Zsombor, Greenhough, Alexander, Malik, Sally, Szemes, Marianna, Park, Ji Hyun, Kaidi, Abderrahmane, Zhou, Li, Catchpoole, Daniel, Morgan, Rhys, Bates, David O., Gabb, Peter J., Malik, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741879/
https://www.ncbi.nlm.nih.gov/pubmed/26517508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741879/
https://www.ncbi.nlm.nih.gov/pubmed/26517508

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