Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Glioblastoma Multiforme (GBM) is the most common and aggressive human brain tumor, associated with very poor survival despite surgery, radiotherapy and chemotherapy. The epidermal growth factor receptor (EGFR) and the platelet-derived growth factor receptor β (PDGFRβ) are hallmarks in GBM with drivi...

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Detalles Bibliográficos
Autores principales: Camorani, Simona, Crescenzi, Elvira, Colecchia, David, Carpentieri, Andrea, Amoresano, Angela, Fedele, Monica, Chiariello, Mario, Cerchia, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741949/
https://www.ncbi.nlm.nih.gov/pubmed/26461476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741949/
https://www.ncbi.nlm.nih.gov/pubmed/26461476

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